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As a result, the MACE event rate varied substantially for participants assigned to placebo, being greatest in EMPA-REG OUTCOME (43.9 per 1,000 patient-years), followed by CREDENCE (38.7 per 1,000 patient-years), CANVAS (31.5 per 1,000 patient-years), and finally DECLARE TIMI-58 (24.2 per 1,000 patient-years)

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